95847-70-4|Ipsapirone|1,1-Dioxo-2-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-1,2-benzothiazol-3-one|-范德生物科技公司

Ipsapirone

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names：
1,1-Dioxo-2-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-1,2-benzothiazol-3-one
CAS号：
95847-70-4
MDL Number：
MF(分子式)： C19H23N5O3S MW(分子量)： 401.48
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	Ipsapirone
英文别名	BAY q 7821; BAY q-7821; BAY q7821; Ipsapirone
CAS号	95847-70-4
Inchi	InChI=1S/C19H23N5O3S/c25-18-16-6-1-2-7-17(16)28(26,27)24(18)11-4-3-10-22-12-14-23(15-13-22)19-20-8-5-9-21-19/h1-2,5-9H,3-4,10-15H2
InchiKey	TZJUVVIWVWFLCD-UHFFFAOYSA-N
分子式 Formula	C19H23N5O3S
分子量 Molecular Weight	401.48
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Ipsapirone(CAS:95847-70-4 ):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Ipsapirone, also known as BAY q 7821, is a new pyrimidinylpiperazine ligand potent and specific for 5-HT1A receptors. Ipsapirone hydrochloride has potential therapeutic use in affective disorders.
Application1
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警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

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[2]Kishi T, Meltzer HY, Matsuda Y, Iwata N. Azapirone 5-HT1A receptor partial agonist treatment for major depressive disorder: systematic review and meta-analysis. Psychol Med. 2014 Aug;44(11):2255-69. doi: 10.1017/S0033291713002857. Epub 2013 Nov 21. Review. PubMed PMID: 24262766.

[3] Fox MA, Andrews AM, Wendland JR, Lesch KP, Holmes A, Murphy DL. A pharmacological analysis of mice with a targeted disruption of the serotonin transporter. Psychopharmacology (Berl). 2007 Dec;195(2):147-66. Epub 2007 Aug 22. Review. PubMed PMID: 17712549.

[4] Chessick CA, Allen MH, Thase M, Batista Miralha da Cunha AB, Kapczinski FF, de Lima MS, dos Santos Souza JJ. Azapirones for generalized anxiety disorder. Cochrane Database Syst Rev. 2006 Jul 19;(3):CD006115. Review. PubMed PMID: 16856115.

[5] de Boer SF, Koolhaas JM. 5-HT1A and 5-HT1B receptor agonists and aggression: a pharmacological challenge of the serotonin deficiency hypothesis. Eur J Pharmacol. 2005 Dec 5;526(1-3):125-39. Epub 2005 Nov 28. Review. PubMed PMID: 16310183.

6: Sobczak S, Honig A, van Duinen MA, Riedel WJ. Serotonergic dysregulation in bipolar disorders: a literature review of serotonergic challenge studies. Bipolar Disord. 2002 Dec;4(6):347-56. Review. PubMed PMID: 12519094.7: Gorman JM. Treatment of generalized anxiety disorder. J Clin Psychiatry. 2002;63 Suppl 8:17-23. Review. PubMed PMID: 12044104.8: Stamford JA, Davidson C, McLaughlin DP, Hopwood SE. Control of dorsal raphé 5-HT function by multiple 5-HT(1) autoreceptors: parallel purposes or pointless plurality? Trends Neurosci. 2000 Oct;23(10):459-65. Review. PubMed PMID: 11006462.9: Cowen PJ. Psychopharmacology of 5-HT(1A) receptors. Nucl Med Biol. 2000 Jul;27(5):437-9. Review. PubMed PMID: 10962247.10: Weihrauch TR. [Placebo effects and adverse effects in clinical trials]. Med Klin (Munich). 2000 May;95(1 Spec No):23-30. Review. German. PubMed PMID: 10851845.1

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