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瑞德西韦三磷酸

瑞德西韦三磷酸(GS-443902,1355149-45-9;Remdesivir triphosphate) 是一种较为有效的病毒RNA依赖的RNA聚合酶 (RdRp) 的抑制剂,对TP RdRp,RSV RdRp 和 HCV RdRp 的 IC50 分别为 5.6 μM,1.1 μM 和 5 μM。GS-443902 属于三磷酸盐衍生产物。
货品编码 规格 纯度 价格 (¥) 现价(¥) 特价(¥) 库存描述 数量 总计 (¥)
HCQ000015-1mg 1mg ≥95% ¥ 4500.00 ¥ 4500.00 backorder
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¥ 0.00
HCQ000015-5mg 5mg ≥95% ¥ 12500.00 ¥ 12500.00 backorder
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¥ 0.00
HCQ000015-20mg 20mg ≥95% ¥ 22500.00 ¥ 22500.00 backorder
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¥ 0.00
HCQ000015-100mg 100mg ≥95% ¥ 0.00 ¥ 0.00 backorder
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中文别名 瑞德西韦三磷酸钠盐衍生物;瑞德西韦三磷酸;1355149-45-9;瑞德西韦衍生物;瑞德西韦三磷酸
英文别名 GS-443902;GS 443902;GS443902;1355149-45-9;Remdesivir monophosphate;[[(2R,3S,4R,5R)-5-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
CAS号 1355149-45-9
SMILES c1cc(n2c1c(ncn2)N)[C@]3([C@@H]([C@@H]([C@H](O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)C#N
Inchi InChI=1S/C12H16N5O13P3/c13-4-12(8-2-1-6-11(14)15-5-16-17(6)8)10(19)9(18)7(28-12)3-27-32(23,24)30-33(25,26)29-31(20,21)22/h1-2,5,7,9-10,18-19H,3H2,(H,23,24)(H,25,26)(H2,14,15,16)(H2,20,21,22)/t7-,9-,10-,12+/m1/s1
InchiKey DFVPCNAMNAPBCX-LTGWCKQJSA-N
分子式 Molecular Weight C12H16N5O17P3
分子量 Formula 531.2
闪点 FP Not available
熔点 Melting point Not available
沸点 Boiling point Not available
Polarizability极化度 39.0±0.5 10-24cm3
密度 Density 2.4±0.1 g/cm3
蒸汽压 Vapor Pressure Not Avialble
溶解度Solubility 易溶于水,不易溶于有机溶剂
性状 白色粉色粉末
储藏条件 Storage conditions -20℃下存储,2-3years;常温下极容易潮解;低温氮气条件下保存。
产品说明 瑞德西韦三磷酸(GS-443902,1355149-45-9,Remdesivir triphosphate) 是一种有效的病毒RNA依赖的 RNA 聚合酶 (RdRp) 的抑制剂,对 TP RdRp,RSV RdRp 和 HCV RdRp 的 IC50 分别为 5.6 μM,1.1 μM 和 5 μM。GS-443902属于三磷酸盐衍生产物。
IntroductionRemdesivir triphosphate(GS-443902,1355149-45-9) IC50: 1.1 μM (RSV RdRp) and 5 μM (HCV RdRp)
Application1Remdesivir triphosphate is a is a potent viral RNA-dependent RNA-polymerases (RdRp) inhibitor. It is the active triphosphate metabolite of Remdesivir.
Application2
Application3
警示图
危险性
危险性警示 Not available
安全声明 H332; H403
安全防护 P332+P313; P305+P351+P338
备注 实验过程防止食如、吸入
【1】. Warren TK, et al. Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys. Nature. 2016 Mar 17;531(7594):381-5.
【2】Cho A, et al. Synthesis and antiviral activity of a series of 1'-substituted 4-aza-7,9-dideazaadenosine C-nucleosides. Bioorg Med Chem Lett. 2012 Apr 15;22(8):2705-7.
【3】Gilead Sciences, Foster City, California 94404, USA.
【4】United States Army Medical Research Institute of Infectious Diseases, Therapeutic Development Center, Frederick, Maryland 21702, USA.
【5】 The nucleoside analog GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies B.G. Murphy, M. Perron, E. Murakami, K. Bauer, Y. Park, C. Eckstrand, M. Liepnieks, N.C. Pedersen Vet Microbiol. 2018 Jun; 219: 226–233. Published online 2018 Apr 22. doi: 10.1016/j.vetmic.2018.04.026 PMCID: PMC7117434
【6】 Development and validation of a UHPLC-MS/MS method for quantification of the prodrug remdesivir and its metabolite GS-441524: a tool for clinical pharmacokinetics of SARS-CoV-2/COVID-19 and Ebola virus disease Valeria Avataneo, Amedeo de Nicolò, Jessica Cusato, Miriam Antonucci, Alessandra Manca, Alice Palermiti, Catriona Waitt, Stephen Walimbwa, Mohammed Lamorde, Giovanni di Perri, Antonio D’Avolio J Antimicrob Chemother. 2020 May 3 : dkaa152. Published online 2020 May 3. doi: 10.1093/jac/dkaa152 PMCID: PMC7197584
【7】Efficacy and safety of the nucleoside analog GS-441524 for treatment of cats with naturally occurring feline infectious peritonitis Niels C Pedersen, Michel Perron, Michael Bannasch, Elizabeth Montgomery, Eisuke Murakami, Molly Liepnieks, Hongwei Liu J Feline Med Surg. 2019 Apr; 21(4): 271–281. Published online 2019 Feb 13. doi: 10.1177/1098612X19825701 PMCID: PMC6435921
【8】 Current knowledge about the antivirals remdesivir (GS-5734) and GS-441524 as therapeutic options for coronaviruses E. Susan Amirian, Julie K. Levy One Health. 2020 Jun; 9: 100128. Published online 2020 Mar 27. doi: 10.1016/j.onehlt.2020.100128 PMCID: PMC7118644
 【9】Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease Maria L. Agostini, Erica L. Andres, Amy C. Sims, Rachel L. Graham, Timothy P. Sheahan, Xiaotao Lu, Everett Clinton Smith, James Brett Case, Joy Y. Feng, Robert Jordan, Adrian S. Ray, Tomas Cihlar, Dustin Siegel, Richard L. Mackman, Michael O. Clarke, Ralph S. Baric, Mark R. Denison mBio. 2018 Mar-Apr; 9(2): e00221-18. Published online 2018 Mar 6. doi: 10.1128/mBio.00221-18 PMCID: PMC5844999
【10】Remdesivir and SARS-CoV-2: structural requirements at both nsp12 RdRp and nsp14 Exonuclease active-sites
Ashleigh Shannon, Nhung Thi Tuyet Le, Barbara Selisko, Cecilia Eydoux, Karine Alvarez, Jean-Claude Guillemot, Etienne Decroly, Olve Peersen, Francois Ferron, Bruno Canard Antiviral Res. 2020 Apr 10 : 104793. doi: 10.1016/j.antiviral.2020.104793 [Epub ahead of print] PMCID: PMC7151495
【11】Remdesivir: A Review of Its Discovery and Development Leading to Emergency Use Authorization for Treatment of COVID-19 Richard T. Eastman, Jacob S. Roth, Kyle R. Brimacombe, Anton Simeonov, Min Shen, Samarjit Patnaik, Matthew D. Hall ACS Cent Sci. 2020 May 4 : acscentsci.0c00489. Published online 2020 May 4. doi: 10.1021/acscentsci.0c00489 PMCID: PMC7202249
【12】Artificial intelligence approach fighting COVID-19 with repurposing drugs Yi-Yu Ke, Tzu-Ting Peng, Teng-Kuang Yeh, Wen-Zheng Huang, Shao-En Chang, Szu-Huei Wu, Hui-Chen Hung, Tsu-An Hsu, Shiow-Ju Lee, Jeng-Shin Song, Wen-Hsing Lin, Tung-Jung Chiang, Jiunn-Horng Lin, Huey-Kang Sytwu, Chiung-Tong Chen Biomed J. 2020 May 15 doi: 10.1016/j.bj.2020.05.001 [Epub ahead of print] PMCID: PMC7227517
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