139689-10-4|SKF-77434, (S)-|(S)-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol|-范德生物科技公司

SKF-77434, (S)-

NMR下载 COA and HPLC MSDS下载
names：
(S)-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol
CAS号：
139689-10-4
MDL Number：
MF(分子式)： C19H21NO2 MW(分子量)： 295.38
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	(S)-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol
英文别名	SKF-77434, (S)-; S-(-)-SKF-77434; J482.833J; S-(-)-Apd;
CAS号	139689-10-4
SMILES	OC1=C(O)C=C2[C@H](C3=CC=CC=C3)CN(CC=C)CCC2=C1
Inchi	InChI=1S/C19H21NO2/c1-2-9-20-10-8-15-11-18(21)19(22)12-16(15)17(13-20)14-6-4-3-5-7-14/h2-7,11-12,17,21-22H,1,8-10,13H2/t17-/m0/s1
InchiKey	QBUVZVXIRYFENV-KRWDZBQOSA-N
分子式 Formula	C19H21NO2
分子量 Molecular Weight	295.38
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	SKF-77434, (S)-(CAS:139689-10-4):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	SKF-77,434 is a drug which acts as a selective dopamine D1 receptor partial agonist, and has stimulant and anorectic effects.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Cauli O, Morelli M. Subchronic caffeine administration sensitizes rats to the motor-activating effects of dopamine D(1) and D(2) receptor agonists. Psychopharmacology (Berl). 2002 Jul;162(3):246-54. Epub 2002 May 14. PubMed PMID: 12122482.

[2]Mutschler NH, Bergman J. Effects of chronic administration of the D1 receptor partial agonist SKF 77434 on cocaine self-administration in rhesus monkeys. Psychopharmacology (Berl). 2002 Apr;160(4):362-70. Epub 2002 Feb 12. PubMed PMID: 11919663.

[3] Schindler CW, Gilman JP, Bergman J, Mello NK, Woosley RL, Goldberg SR. Interactions between cocaine and dopamine agonists on cardiovascular function in squirrel monkeys. J Pharmacol Exp Ther. 2002 Jan;300(1):180-7. PubMed PMID: 11752114.

[4] Platt DM, Rowlett JK, Spealman RD. Modulation of cocaine and food self-administration by low- and high-efficacy D1 agonists in squirrel monkeys. Psychopharmacology (Berl). 2001 Sep;157(2):208-16. PubMed PMID: 11594448.

[5] Caine SB, Negus SS, Mello NK, Bergman J. Effects of dopamine D1-like and D2-like agonists in rats trained to discriminate cocaine from saline: influence of experimental history. Exp Clin Psychopharmacol. 2000 Aug;8(3):404-14. PubMed PMID: 10975632.

6: Platt DM, Rowlett JK, Spealman RD. Dissociation of cocaine-antagonist properties and motoric effects of the D1 receptor partial agonists SKF 83959 and SKF 77434. J Pharmacol Exp Ther. 2000 Jun;293(3):1017-26. PubMed PMID: 10869406.7: Caine SB, Negus SS, Mello NK, Bergman J. Effects of dopamine D(1-like) and D(2-like) agonists in rats that self-administer cocaine. J Pharmacol Exp Ther. 1999 Oct;291(1):353-60. PubMed PMID: 10490924.8: Katz JL, Kopajtic TA, Myers KA, Mitkus RJ, Chider M. Behavioral effects of cocaine: interactions with D1 dopaminergic antagonists and agonists in mice and squirrel monkeys. J Pharmacol Exp Ther. 1999 Oct;291(1):265-79. PubMed PMID: 10490913.9: Tidey JW, Bergman J. Drug discrimination in methamphetamine-trained monkeys: agonist and antagonist effects of dopaminergic drugs. J Pharmacol Exp Ther. 1998 Jun;285(3):1163-74. PubMed PMID: 9618419.10: Abrahams BS, Rutherford JD, Mallet PE, Beninger RJ. Place conditioning with the dopamine D1-like receptor agonist SKF 82958 but not SKF 81297 or SKF 77434. Eur J Pharmacol. 1998 Feb 19;343(2-3):111-8. PubMed PMID: 9570457.1

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