1010081-09-0|Antroquinonol|(4R,5R,6R)-4-hydroxy-2,3-dimethoxy-6-methyl-5-((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)cyclohex-2-en-1-one|-范德生物科技公司

Antroquinonol

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names：
(4R,5R,6R)-4-hydroxy-2,3-dimethoxy-6-methyl-5-((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)cyclohex-2-en-1-one
CAS号：
1010081-09-0
MDL Number：
MF(分子式)： C24H38O4 MW(分子量)： 390.56
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Antroquinonol
英文别名
CAS号	1010081-09-0
SMILES	O=C1C(OC)=C(OC)[C@H](O)[C@H](C/C=C(C)/CC/C=C(C)/CC/C=C(C)\C)[C@H]1C
Inchi	InChI=1S/C24H38O4/c1-16(2)10-8-11-17(3)12-9-13-18(4)14-15-20-19(5)21(25)23(27-6)24(28-7)22(20)26/h10,12,14,19-20,22,26H,8-9,11,13,15H2,1-7H3/b17-12+,18-14+/t19-,20-,22-/m1/s1
InchiKey	LJTSIMVOOOLKOL-FNRDIUJOSA-N
分子式 Formula	C24H38O4
分子量 Molecular Weight	390.56
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Antroquinonol(CAS:1010081-09-0):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Antroquinonol is potentially for the treatment of non-small cell lung cancer.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Hu YD, Lu RQ, Liao XR, Zhang BB, Xu GR. Stimulating the biosynthesis of antroquinonol by addition of effectors and soybean oil in submerged fermentation of Antrodia camphorata. Biotechnol Appl Biochem. 2016 May;63(3):398-406. doi: 10.1002/bab.1387. PubMed PMID: 25906825.

[2]Thiyagarajan V, Tsai MJ, Weng CF. Antroquinonol Targets FAK-Signaling Pathway Suppressed Cell Migration, Invasion, and Tumor Growth of C6 Glioma. PLoS One. 2015 Oct 30;10(10):e0141285. doi: 10.1371/journal.pone.0141285. PubMed PMID: 26517117; PubMed Central PMCID: PMC4627804.

[3] Hsu CY, Sulake RS, Huang PK, Shih HY, Sie HW, Lai YK, Chen C, Weng CF. Synthetic (+)-antroquinonol exhibits dual actions against insulin resistance by triggering AMP kinase and inhibiting dipeptidyl peptidase IV activities. Br J Pharmacol. 2015 Jan;172(1):38-49. doi: 10.1111/bph.12828. PubMed PMID: 24977411; PubMed Central PMCID: PMC4280966.

[4] Xia Y, Zhou X, Wang G, Zhang B, Xu G, Ai L. Induction of antroquinonol production by addition of hydrogen peroxide in the fermentation of Antrodia camphorata S-29. J Sci Food Agric. 2017 Jan;97(2):595-599. doi: 10.1002/jsfa.7770. PubMed PMID: 27098319.

[5] Ho CL, Wang JL, Lee CC, Cheng HY, Wen WC, Cheng HH, Chen MC. Antroquinonol blocks Ras and Rho signaling via the inhibition of protein isoprenyltransferase activity in cancer cells. Biomed Pharmacother. 2014 Oct;68(8):1007-14. doi: 10.1016/j.biopha.2014.09.008. PubMed PMID: 25312820.

6: Wang SC, Lee TH, Hsu CH, Chang YJ, Chang MS, Wang YC, Ho YS, Wen WC, Lin RK. Antroquinonol D, isolated from Antrodia camphorata, with DNA demethylation and anticancer potential. J Agric Food Chem. 2014 Jun 18;62(24):5625-35. doi: 10.1021/jf4056924. PubMed PMID: 24784321.7: Lee YC, Ho CL, Kao WY, Chen YM. A phase I multicenter study of antroquinonol in patients with metastatic non-small-cell lung cancer who have received at least two prior systemic treatment regimens, including one platinum-based chemotherapy regimen. Mol Clin Oncol. 2015 Nov;3(6):1375-1380. PubMed PMID: 26807250; PubMed Central PMCID: PMC4665158.8: Chang WH, Chen MC, Cheng IH. Antroquinonol Lowers Brain Amyloid-β Levels and Improves Spatial Learning and Memory in a Transgenic Mouse Model of Alzheimer's Disease. Sci Rep. 2015 Oct 15;

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